Endothelin-1 Gene LYS198ASN Polymorphism and Blood Pressure Reactivity
نویسندگان
چکیده
منابع مشابه
Endothelin-1 gene Lys198Asn polymorphism and blood pressure reactivity.
The Lys198Asn polymorphism of the endothelin-1 gene has been associated with increased blood pressure levels in several studies involving European and Australian adults. The purpose of the present study was to examine the potential moderating influence of ethnicity, obesity, and socioeconomic status on associations between the ET-1/Lys198Asn polymorphism and hemodynamic function at rest and dur...
متن کاملThe Lys198Asn polymorphism in the endothelin-1 gene is associated with blood pressure in overweight people.
There is accumulating evidence that endothelin-1 plays an important role in vascular pathophysiology. Our objective was to examine whether molecular variations at the endothelin-1 locus were involved in susceptibility to myocardial infarction and variation in blood pressure. The entire coding sequence and 1.4 kb of the 5' flanking region were screened. Five polymorphisms were detected, which we...
متن کاملEvaluation of the Lys198Asn and -134delA genetic polymorphisms of the endothelin-1 gene.
Endothelin-1 (ET-1) is a potent vasoconstrictor and shows various pharmacological responses. Two single nucleotide polymorphisms in the ET-1 gene (EDN1) have been reported to be associated with blood pressure (BP). One is the Lys198Asn polymorphism, which showed a positive association with BP in overweight people. Another is the 3A/4A polymorphism (-134delA) located in the 5'-untranslated regio...
متن کاملThe Effect of Resistance Training on Plasma Levels of Endothelin 1 and Blood Pressure in Older Men
Introduction: Endothelin 1, which is secreted by vascular endothelial cells, has been identified as the most potent vasoconstrictor. The purpose of this study was to investigate the effect of a course of endothelin-1 plasma resistance training and its relationship with blood pressure in older men. Methods: In this quasi-experimental study, 30 elderly men (mean age 62.28 ± 8.08 years, height 17...
متن کاملEndothelin-1 gene and progression of blood pressure and left ventricular mass: longitudinal findings in youth.
Endothelin-1 (ET-1) is a powerful vasconstrictor peptide implicated in development of essential hypertension and left ventricular hypertrophy. To evaluate the impact of genetic variability of the ET-1 gene on progression of blood pressure (BP) and left ventricular mass (LVM), we conducted individual growth curve modeling for 537 European American and black youths with 12 assessments during a 15...
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ژورنال
عنوان ژورنال: Hypertension
سال: 2003
ISSN: 0194-911X,1524-4563
DOI: 10.1161/01.hyp.0000091266.41333.15